Basal ganglia: Caudate nucleus, Putamen, Substantia nigra and Lateral ventricles
Source:
stemcells.nih.gov
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Location of the basal ganglia. Source:
hopes.stanford.edu (edited)
Disorders: Cerebral palsy, Dystonia;
Parkinson's Disease,
Huntington's Disease
S;
Lesch-Nyhan syndrome,
Obsessive-Compulsive Disorder
S;
ADHD
S,
S,
Tourette Syndrome
S,
Stuttering, Wilson's disease; Schizophrenia
S;
Depression
S;
Sexual disorders
S,
Neurodegeneration associated with brain iron accumulation
S
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Functions: Motor skills; motion selection, initiation and control:
information transfer from the (P)FC and the
parietal cortex via the
basal ganglia and the thalamus up to the
SMA (part of the motor cortex);
above all inhibition of unwanted/ inappropriate movements but also
coordination of volitional movements, postures
S
Procedural memory
Attention (dopamine)
S;
processing of different emotional and cognitive stimuli (reward system,
reinforcement, Addiction, habits)
S
(see below)
Modulation of pain perception
S
Quod vide:
Claustrum,
Striatum,
Nucleus caudatus,
Globus pallidus,
Nucleus accumbens und
Putamen
|
Putamen. Source
|
Claustrum
Functions: Consciousness; joining of different attributes into one object
(sensory synchronization);
synchronization of different perceptual, cognitive and motor modalities
S;
claustrocortical network for sensory integration
S
Processing of visual sexual stimuli
Caudate nucleus
Functions: Movement control
S,
Motor memory (Dopamine)
S
Language control (left: changes in the language or the meaning of words)
S;
Speech processing (e.g. ambivalence)
S
Perceptual skill learning
S;
Reaction to positive and negative feedback during learning
S,
left hemisphere: detection of a change in the 'context' and the subsequent formulation of a new 'rule'
S;
the linking of action to outcome
S
Obsessions, compulsions
S
Memory S,
working memory
S;
Visualization of emotional events in the near future;
concrete simulations of action plans to achieve rewarding situations in the near future
S
Love S,
motherly love S
Pain S
Disorders:
Obsessive-Compulsive Disorder
S,
S;
Major Depression (left hemisphere)
S,
Parkinson's Disease (Serotonin)
S,
Huntington's Disease
S,
S;
Schizophrenia
S;
Autism
S;
Addiction (Cocaine)
S
Globus pallidus
Functions: Motion facilitation (lateral segment) and motion inhibition (medial segment);
acts as an "antagonist" of the Striatum; sends inhibiting impulses
to the Thalamus and the Nucleus subthalamicus
Important part of the reward system
S
Sexual arousal and behavior
S
Tourette Syndrome (GABA)
S,
Parkinson's Disease (GPI)
S,
Huntington's Disease
S,
Anhedonia/ Depression
S;
Dyskinesia S,
Dystonia S,
Tremor, Acampsia, Bradykinesia; Addiction
(Cocaine; ventral)
S,
loss of craving
S;
Pedophilia
S,
Progressive supranuclear palsy
S
|
Striatum
Functions: 'Entrance' to the basal ganglia;
strong interconnections to the neocortex; attention -> many dopamine receptors
S
Working memory
S;
skill acquisition (cognitive, perceptive, motor)
S
Executive: Interplay of motivation, emotion, cognition and motion
on a neuronal level
Activation by rewards
S
(dopamine, ventral) S
and by aversive, novel, unexpected or very intense stimuli
Sexual arousal and behavior
S
* Ventral: Preparation, initiation and execution of reward-related
behavior as a result of successful integration of (relevant) emotional
and cognitive information (strong connections to the OFC
and the ACC)
S
even when rewards were cued but omitted
S
* Dorsal: Reward system, adjustments after delivered rewards
S,
categorization
S
Disorders: Striatofrontal dysfunction: Depression
S,
S,
Chronic Schizophrenia
S,
Obsessive-Compulsive Disorder
S
(serotonergic hypofunction),
Borderline PD
S,
Pedophilia
S,
ADHD
S,
Tremor S,
Parkinson's Disease (Dopamine),
Huntington's Disease (GABA)
S,
S;
Athetosis, Dyskinesia; Addiction (Dopamine)
S,
S;
Anorexia Nervosa
S
Nucleus accumbens
Functions: Important part of the reward system,
emotional learning, operant conditioning, motivation
S,
selbst-reference
S;
sympathy/ preference (unknown faces)
S;
empathy/ friendship
S;
craving S
Disorders: Addiction
S,
Depression
S,
S;
Bipolar Disorder
S
Putamen
Functions: Reinforcement learning;
efficiency S
Motor memory (Dopamine)
S
Speech processing (e.g. ambivalence)
S
Disorders: Huntington's Disease
S,
Parkinson's Disease (Serotonin)
S,
Obsessive-Compulsive Disorder
S;
Addiction (Cocaine)
S
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